Mouse models - FinGMice
Platform services
Mouse models
- Generation, analysis, and archiving of GM mice
- Systematic phenotyping of GM mice
- Mouse pathology
Mouse models - FinGMice
Genetically modified (GM) mice have become the most important model organisms to understand the molecular basis of health and disease in man and to serve as suitable animal models for human disease. They thus have an important role in the development of new therapeutic approaches to human diseases. Work with GM mice requires high level of expertise, and specific ethical and legistlative issues according to 3Rs are followed.
Core facilities with experienced personnel provide high quality service in generation, analysis, and archiving of GM mice. Large international projects to systemically produce mutations in all genes in the mouse genome and CRISPR/Cas methodology facilitate the work with GM mice. Local infrastructure is essential for providing services in customized mutagenesis and expertise in all aspects of mouse related issues, such as generation and archiving of mutant mouse lines, as well as in training.
Highly specialized personnel and modern facilities are also required in systematic phenotyping of GM mice. Currently, services are provided by the Neurophenotyping Center (NCP) in Helsinki and Kuopio, Turku Center for Disease Modeling, and Biocenter Oulu.
More information about GM mouse work in Finland: www.FinGMice.org
International Mouse projects with Finnish participation: www.Infrafrontier.eu
Generation, analysis, and archiving of GM mice
Helsinki Institute of Life Science - HiLIFE
Helsinki GM Mouse Unit
Biocenter Oulu
Biocenter Oulu Transgenic and Tissue Phenotyping Core Facility
BioCity Turku
Turku Center for Disease Modeling (TCDM) Mouse Biology and Genetics Unit
Systematic phenotyping of GM mice
Helsinki Institute of Life Science - HiLIFE
Neuroscience Center Mouse Behavioural Phenotyping Facility (MBPF)
Biocenter Kuopio
UEF Phenotyping Center
BioCityTurku
Turku Center for Disease Modeling (TCDM)
Biocenter Oulu
Biocenter Oulu Transgenic and Tissue Phenotyping Core Facility
Mouse pathology
Finnish Centre for Laboratory Animal Pathology (FCLAP) provide expertise in mouse pathology
Contacts
Platform Coordinator
Reetta Hinttala / +358-(0)294 486135 / reetta.hinttala (at) oulu.fi
Biocenter Oulu, University of Oulu
Biocenter Oulu Transgenic and Tissue Phenotyping Core Facility
Mouse models platform partners
Reetta Hinttala, Transgenic Core Facility, Biocenter Oulu; Satu Kuure, GM unit, Laboratory Animal Center, HiLIFE; Pirjo Laakkonen, Laboratory Animal Center, HiLIFE; Jere Lindén and Antti Sukura, Finnish Centre for Laboratory Animal Pathology (FCLAP); Petra Sipilä and Matti Poutanen, Turku Center for Disease Modeling (TCDM), BioCity; Heikki Tanila, Neurophenotyping Center (with MBPF), Biocenter Kuopio (BCK); Vootele Võikar, Mouse Behavioral Phenotyping Facility (MBPF), Neurophenotyping Center (with BCK), HiLIFE