Contact details
Platform Chair
Päivi Tammela
paivi.tammela@helsinki.fi
Nodes
UEF: University of Eastern Finland; UH: University of Helsinki; UTU: University of Turku, ÅAU: Åbo Akademi University
Services
- Project and assay guidance and development support – all sites
- Chemical screening and profiling – FIMM and Faculty of Pharmacy, UH; BioCity Turku
- Drug sensitivity and resistance screening (DSRT) and drug repurposing – FIMM, UH
- Imaging-based high-throughput screening – FIMM, UH, BioCity Turku
- Antimicrobial screening and follow-up assays – Faculty of Pharmacy, UH
- Chemoinformatics, molecular modeling, and virtual screening – Biocenter Kuopio, Faculty of Pharmacy, UH, and BioCity Turku – SBL-Computational Drug Design, ÅAU
- Synthesis of novel drug candidates and hit/lead optimisation – Biocenter Kuopio - UEF-MCOS
- Follow-up screening and testing – all sites
- Access to a large national chemical collection – FIMM
Recent user publications
Momeny M, Tienhaara M, Sharma M, Chakroborty D, Varjus R, Takala I, Merisaari J, Padzik A, Vogt A, Paatero I, Elenius K, Laajala TD, Kurppa KJ, Westermarck J. DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer. EMBO Mol Med. 2024, 16, 1603-1629. doi: 10.1038/s44321-024-00088-0
Ali AE, Li LL, Courtney MJ, Pentikäinen OT, Postila PA. Atomistic simulations reveal impacts of missense mutations on the structure and function of SynGAP1. Brief Bioinform. 2024, 25, bbae458. doi: 10.1093/bib/bbae458
Saadabadi A, Wilkman L, Rantanen M, Koivisto A-P, Salo-Ahen OMH: Structure- and Ligand-Based Virtual Screening for Identification of Novel TRPV4 Antagonists. Molecules. 2025, 30, 100. doi: 10.3390/molecules30010100
Ianevski A, Nader K, Driva K, Senkowski W, Bulanova D, Moyano-Galceran L, Ruokoranta T, Kuusanmäki H, Ikonen N, Sergeev P, Vähä-Koskela M, Giri AK, Vähärautio A, Kontro M, Porkka K, Pitkänen E, Heckman CA, Wennerberg K, Aittokallio T. Single-cell transcriptomes identify patient-tailored therapies for selective co-inhibition of cancer clones. Nat Commun. 2024, 15, 8579. https://doi.org/10.1038/s41467-024-52980-5
Heininen J, Movahedi P, Kotiaho T, Kostiainen R, Pahikkala T, Teppo J. Targeted and Untargeted Amine Metabolite Quantitation in Single Cells with Isobaric Multiplexing.Chem. Eur. J. 2024, 30, e202403278. https://doi.org/10.1002/chem.202403278
Bogacheva MS, Kuivanen S, Potdar S, Hassinen A, Huuskonen S, Pöhner I, Luck TJ, Turunen L, Feodoroff M, Szirovicza L, Savijoki K, Saarela J, Tammela P, Paavolainen L, Poso A, Varjosalo M, Kallioniemi O, Pietiäinen V, Vapalahti O. Drug repurposing platform for deciphering the druggable SARS-CoV-2 interactome. Antiviral Research. 2024, 223, 105813. https://doi.org/10.1016/j.antiviral.2024.105813
Pozzetti L, East MP, Laitinen T, Asquith CRM. TLK2: a target for cancer and viral latency. Nat. Rev. Drug Discov. 2024, 23, 886-886. https://doi.org: 10.1038/d41573-024-00163-8
